<i>Salmonella</i> Typhi Vi capsule prime-boost vaccination induces convergent and functional antibody responses
Lindsay C. Dahora, Marije K. Verheul, Katherine L. Williams, Celina Jin, Lisa Stockdale, Guy Cavet, Eldar Giladi, Jennifer Hill, Dongkyoon Kim, Yvonne Leung, Benjamin G. Bobay, Leonard D. Spicer, Sheetal Sawant, Sjoerd Rijpkema, S. Moses Dennison, S. Munir Alam, Andrew J. Pollard, Georgia D. Tomaras
Abstract
Typhi Vi and enriching for antibody Fc functions that protect against typhoid fever will advance the design of high-efficacy Vi vaccines for protection across diverse populations.
Topics & Concepts
AvidityEpitopeAntibodyBiologyConjugate vaccineToxoidVirologySalmonella typhiImmunizationImmunologyAntigenAntibody opsonizationMicrobiologyOpsoninEscherichia coliBiochemistryGeneSalmonella and Campylobacter epidemiologyViral gastroenteritis research and epidemiologyBacteriophages and microbial interactions