SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration
Matthew D. Figley, Weixi Gu, Jeffrey D. Nanson, Yun Shi, Yo Sasaki, Katie Cunnea, Alpeshkumar K. Malde, Xinying Jia, Zhenyao Luo, Forhad Karim Saikot, Tamim Mosaiab, Veronika Masic, Syndee Holt, Lauren E. Hartley‐Tassell, Helen Y. McGuinness, M.K. Manik, Todd Bosanac, Michael J. Landsberg, Philip S. Kerry, Mehdi Mobli, Robert Hughes, Jeffrey Milbrandt, Boštjan Kobe, Aaron DiAntonio, Thomas Ve
Topics & Concepts
NAD+ kinaseAxonDegeneration (medical)NeuroscienceAxonal degenerationChemistryBiologyCell biologyBiochemistryMedicinePathologyEnzymeBiochemical effects in animalsEndoplasmic Reticulum Stress and DiseaseSirtuins and Resveratrol in Medicine