Antibiotic Exposure and Risk for Hospital-Associated Clostridioides difficile Infection
Brandon Webb, Aruna Subramanian, Bert K. Lopansri, Bruce Goodman, Peter Jones, Jeffrey P. Ferraro, Edward Stenehjem, Samuel M. Brown
Abstract
< 0.0001). The highest-risk antibiotics included second-generation and later cephalosporins (especially oral), carbapenems, fluoroquinolones, and clindamycin, while doxycycline and daptomycin were associated with a lower CDI risk. We concluded that cumulative antibiotic exposure prior to admission is the greatest contributor to the risk of subsequent CDI. Most classes of antibiotics carry some risk, which varies by drug and route. This information may be useful for antimicrobial stewardship efforts.
Topics & Concepts
ClostridioidesMedicineRetrospective cohort studyHealth careEmergency medicineCohortClostridium difficileAntibioticsIntensive care medicineInternal medicineMicrobiologyBiologyEconomic growthEconomicsClostridium difficile and Clostridium perfringens researchMicroscopic ColitisNosocomial Infections in ICU