Nicotinamide <i>N</i>-Methyltransferase Remodeled Cell Metabolism and Aggravated Proinflammatory Responses by Activating STAT3/IL1β/PGE<sub>2</sub> Pathway
Changmei Yang, Tianxiang Wang, Songbiao Zhu, Zhaoyun Zong, Chengting Luo, Yujiao Zhao, Jing Liu, Ting Li, Xiaohui Liu, Chongdong Liu, Haiteng Deng
Abstract
axis and proposed that NNMT was a potential therapeutic target for cancer treatment.
Topics & Concepts
Proinflammatory cytokineNicotinamideChemistryMethyltransferaseSTAT3NAD+ kinaseCell biologyBiochemistryInflammationCancer researchSignal transductionMethylationBiologyEnzymeImmunologyGeneAdenosine and Purinergic SignalingRNA modifications and cancerEpigenetics and DNA Methylation