Ubiquitination‐Dependent LLGL2 Degradation Drives Colorectal Cancer Progression via <i>THBS3</i> mRNA Stabilization (Adv. Sci. 39/2025)
Jiayan Huang, Tiantian Zhang, Huimin Li, Zongxiang Li, Shuangshuang Yin, Yiman Liu, Chunze Zhang, Yuling Qiu, Haiyang Yu
Abstract
Colorectal Cancer The cover art portrays the Chinese myth of “Yu Casting the Nine Cauldrons,” where a serpent attempts to drag away the sacred cauldron while Yu fights to protect it. This mirrors the progression of CRC: MDM2 ubiquitinates and degrades LLGL2 protein, thereby stabilizing THBS3 expression and activating the PI3K-Akt pathway to drive tumor growth. Conversely, CNOT1 binds to LLGL2 to degrade THBS3 mRNA, thus suppressing CRC development. More details can be found in the Research Article by Yuling Qiu, Haiyang Yu, and co-workers (DOI: 10.1002/advs.202501656).
Topics & Concepts
Cancer researchColorectal cancerChemistryMessenger RNACancerMedicineDegradation (telecommunications)MetastasisGene expressionBiologyCancer Research and TreatmentsRNA modifications and cancerCancer, Hypoxia, and Metabolism