Synthesis and biological evaluation of novel D-ring fused steroidal <i>N</i>(2)-substituted-1,2,3-triazoles
Branislava Tenjović, Sofija S. Bekić, Andjelka S. Ćelić, Edward T. Petri, Julia Scholda, Florian Kopp, Marija N. Sakač, Andrea R. Nikolić
Abstract
(2)-substituted-1,2,3-triazoles are high-affinity ligands for estrogen receptor β and glucocorticoid receptor, inhibitors of aldo-keto reductase 1C3 enzyme, and exhibit antiproliferative effects against cancer cells, suggesting that they could serve as scaffolds for anticancer drug development.
Topics & Concepts
Ring (chemistry)ChemistryCombinatorial chemistryStereochemistryOrganic chemistrySynthesis and Biological EvaluationSynthesis and biological activityClick Chemistry and Applications