Flow chemistry for process optimisation using design of experiments
Connor J. Taylor, Alastair Baker, Michael Chapman, William R. Reynolds, Katherine E. Jolley, Graeme Clemens, Gill E. Smith, A. John Blacker, Thomas W. Chamberlain, S. Christie, Brian Taylor, Richard A. Bourne
Abstract
Abstract Implementing statistical training into undergraduate or postgraduate chemistry courses can provide high-impact learning experiences for students. However, the opportunity to reinforce this training with a combined laboratory practical can significantly enhance learning outcomes by providing a practical bolstering of the concepts. This paper outlines a flow chemistry laboratory practical for integrating design of experiments optimisation techniques into an organic chemistry laboratory session in which students construct a simple flow reactor and perform a structured series of experiments followed by computational processing and analysis of the results.