Synthesis of polysubstituted 5-trifluoromethyl isoxazoles <i>via</i> denitrogenative cyclization of vinyl azides with trifluoroacetic anhydride
Wei Wu, Qiaoling Chen, Yishi Tian, Yihui Xu, Yangjie Huang, Yi You, Zhiqiang Weng
Abstract
A general method for the synthesis of 5-(trifluoromethyl)isoxazoles by denitrogenative cyclization of vinyl azides with trifluoroacetic anhydride has been developed.
Topics & Concepts
Trifluoroacetic anhydrideChemistryTrifluoromethylOrganic chemistryTrifluoroacetic acidAlkylFluorine in Organic ChemistrySynthesis and Biological EvaluationSynthesis and Catalytic Reactions