Water-enabled <i>α</i>-C(sp<sup>3</sup>)–H amination <i>via</i> [1,6]-hydride transfer: green access to diazepino[6,5,4-<i>cd</i>]indoles
Yao‐Bin Shen, Xiao-Lin Wang, Qian-Hao Zhuang, Xiao‐De An, Bin Qiu, Houchen Wang, Tiesheng Shi, Jian Xiao
Abstract
Water-enabled α -C(sp 3 )–H amination of 4-dialkylamino-indole-3-carbaldehydes with primary amines was developed for green synthesis of diazepino[6,5,4- cd ]indoles via cascade aldimine condensation/[1,6]-hydride transfer/cyclization.
Topics & Concepts
ChemistryHydrideAminationReductive aminationMedicinal chemistryStereochemistryOrganic chemistryHydrogenCatalysisSynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis