Asymmetric allylic substitution–isomerization to axially chiral enamides <i>via</i> hydrogen-bonding assisted central-to-axial chirality transfer
Chao Sun, Xiaotian Qi, Xiao-Long Min, Xue-Dan Bai, Peng Liu, Ying He
Abstract
Axially chiral enamides bearing a N–C axis have been recently studied and were proposed to be valuable chiral building blocks, but a stereoselective synthesis has not been achieved.
Topics & Concepts
Axial symmetryChirality (physics)IsomerizationAxial chiralityAllylic rearrangementSubstitution (logic)StereoselectivityHydrogen bondChemistryStereochemistryComputational chemistryEnantioselective synthesisMoleculeCatalysisPhysicsOrganic chemistryChiral symmetryComputer scienceQuantum mechanicsNambu–Jona-Lasinio modelProgramming languageQuarkAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralityAsymmetric Synthesis and Catalysis