Glutathione-responsive nanoscale MOFs for effective intracellular delivery of the anticancer drug 6-mercaptopurine
Ming Gong, Jian Yang, Yongsheng Li, Jinlou Gu
Abstract
A glutathione-triggered drug delivery system (DDS) based on nanoscale metal-organic frameworks (NMOFs) is developed, which features an intracellular redox-responsive release of an anticancer drug. Compared to normal cells, the current NMOF-based DDS has 3-fold higher cytotoxicity to cancer cells, prefiguring its great potential for selective cancer therapy.
Topics & Concepts
GlutathioneMercaptopurineDrug deliveryDrugChemistryDisulfide bondAnticancer drugIntracellularPharmacologyCombinatorial chemistryNanotechnologyBiochemistryMedicineMaterials scienceEnzymeOrganic chemistryMetal-Organic Frameworks: Synthesis and ApplicationsAdvanced Nanomaterials in CatalysisMXene and MAX Phase Materials