SIRT in 2025
Francesca Romana Ponziani, Francesco Santopaolo, Alessandro Posa, Maurizio Pompili, Alessandro Tanzilli, Marta Maestri, Maria Pallozzi, Francesca Ibba, Riccardo Manfredi, Antonio Gasbarrini, Roberto Iezzi
Abstract
Selective internal radiation therapy represents an endovascular treatment option for patients with primary liver malignancies, in different clinical stages. Potential applications of this treatment are in early-stage hepatocellular carcinoma, as a curative option, or in combination with systemic treatments in intermediate and advanced-stages. This review, based on existing literature and ongoing trials, will focus on the future of this treatment in patients with hepatocellular carcinoma, in combination with systemic treatments, or with the use of new devices and technological developments; it will also describe new potential future indications and structural and organizational perspectives.