Cu‐Catalysed Three‐Component Reaction of Aryldiazonium Salts with Fluorinated Diazo Reagents and Nitriles: Access to Difluoro‐ and Trifluoromethylated <i>N</i><sup>1</sup>‐Aryl‐1,2,4‐triazoles
Xing Peng, Fa‐Guang Zhang, Jun‐An Ma
Abstract
Abstract A copper‐catalysed three‐component reaction of aryldiazonium salts with fluorinated diazo reagents and nitriles is described. This formal [1+2+2] annulation protocol provides rapid access to a diverse array of difluoro‐ and trifluoromethylated N 1 ‐aryl‐1,2,4‐triazoles under simple conditions. The synthetic applicability to divergent drug‐like 1,2,4‐triazoles is also demonstrated. magnified image
Topics & Concepts
ChemistryDiazoReagentAnnulationArylCombinatorial chemistryComponent (thermodynamics)Organic chemistryCatalysisAlkylThermodynamicsPhysicsFluorine in Organic ChemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods