Pathogenic mechanisms involving the interplay between adipose tissue and auto-antibodies in rheumatoid arthritis
I. Arias de la Rosa, Alejandro Escudero‐Contreras, M. Ruiz-Ponce, L. Cuesta-López, Cristóbal Román-Rodríguez, Carlos Pérez-Sánchez, Patricia Ruiz‐Limón, Rocío Guzman- Ruiz, Fernando Leiva‐Cepas, Juan Alcaide, P. Segui, Chamaida Plasencia, Ana Martínez‐Feito, Pilar Font, María C. Ábalos, Rafaela Ortega, Marı́a M. Malagón, Francisco J. Tinahones, Eduardo Collantes‐Estévez, C. López-Pedrera, Nuria Barbarroja
Abstract
experiments with human AT and adipocyte and macrophage cell lines were performed. A collagen-induced arthritis mouse model was developed. The insulin resistance and the altered adipocytokine profile were associated with disease activity, the presence of anti-citrullinated proteins anti-bodies (ACPAs), and worse response to therapy in RA. AT in the context of arthritis is characterized by an inflammatory state alongside the infiltration of macrophages and B/plasmatic cells, where ACPAs can have a direct impact, inducing inflammation and insulin resistance in macrophages and promoting a defective adipocyte differentiation, partially restored by biologicals.