Palladium-Catalyzed Stereoselective C−F Bond Vinylation and Allylation of Tetrasubstituted <i>gem</i>-Difluoroalkenes via Stille Coupling: Synthesis of Monofluorinated 1,3- and 1,4-Dienes
Min Li, Yanhui Wang, Gavin Chit Tsui
Abstract
We herein describe a Pd-catalyzed stereoselective C−F bond vinylation and allylation reaction of tetrasubstituted gem-difluoroalkenes for the synthesis of valuable monofluorinated 1,3- and 1,4-dienes with excellent diastereoselectivities. Different from previously used Pd(PPh3)4, a catalytic system involving Pd(0) and dppe as the ligand was developed for Stille-type cross-coupling between gem-difluoroalkenes and vinyl- and allyltin reagents.
Topics & Concepts
Stille reactionChemistryStereoselectivityReagentCatalysisPalladiumCombinatorial chemistryLigand (biochemistry)Medicinal chemistryOrganic chemistryReceptorBiochemistryFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions