CX3CR1 Is a Receptor for Human Respiratory Syncytial Virus in Cotton Rats
Gia Green, Sara M. Johnson, Heather M. Costello, Kelsey A. Brakel, Olivia Harder, Antonius G. P. Oomens, Mark E. Peeples, Hong M. Moulton, Stefan Niewiesk
Abstract
The knowledge about a virus receptor is useful to better understand the uptake of a virus into a cell and potentially develop antivirals directed against either the receptor molecule on the cell or the receptor-binding protein of the virus. Among a number of potential receptor proteins, human CX3CR1 has been demonstrated to act as a receptor for respiratory syncytial virus (RSV) on human epithelial cells in tissue culture.
Topics & Concepts
BiologyCX3CR1VirologyReceptorVirusCell cultureMolecular biologyMicrobiologyChemokine receptorChemokineBiochemistryGeneticsRespiratory viral infections researchTracheal and airway disordersNeonatal Respiratory Health Research