Visible-Light Optical Coherence Tomography Fibergraphy for Quantitative Imaging of Retinal Ganglion Cell Axon Bundles
David A. Miller, Marta Grannonico, Mingna Liu, Roman V. Kuranov, Peter A. Netland, Xiaorong Liu, Hao F. Zhang
Abstract
Purpose: . Methods: confocal microscopy using semi-log Sholl analysis. Results: = 6). Conclusions: We demonstrated the feasibility of using vis-OCT fibergraphy to visualize RGC axon bundles. Further applying Sholl analysis has the potential to identify biomarkers for non-invasively assessing RGC health. Translational Relevance: provides a potential measurement tool for diagnosing and tracking the progression of optic neuropathies.
Topics & Concepts
Optical coherence tomographyAxonConfocal microscopyRetinal ganglion cellConfocalRetinalEx vivoRetinaIn vivoBiologyMicroscopyAnatomyNeuroscienceOphthalmologyPathologyMedicineOpticsCell biologyPhysicsBiotechnologyGlaucoma and retinal disordersOptical Coherence Tomography ApplicationsRetinal Development and Disorders