Super-enhancer-driven AJUBA is activated by TCF4 and involved in epithelial-mesenchymal transition in the progression of Hepatocellular Carcinoma
Chi Zhang, Wei Shi, Weipeng Sun, Kai Teng, Miaomiao Dai, Feng‐Wei Wang, Jiewei Chen, Ling Han, Xiaodan Ma, Zihao Feng, Jin‐Ling Duan, Muyan Cai, Dan Xie
Abstract
Our results provide functional and mechanistic links between the SE-associated gene AJUBA and tumor EMT in aggressive HCC.
Topics & Concepts
BiologyTranscription factorCancer researchEnhancerGene knockdownOncogeneCell biologyEpithelial–mesenchymal transitionDownregulation and upregulationGeneCell cycleGeneticsUbiquitin and proteasome pathwaysCancer-related gene regulationRNA modifications and cancer