A flexible multiplexed immunosensor for point-of-care in situ wound monitoring
Yuji Gao, Dat T. Nguyen, Trifanny Yeo, Su Bin Lim, Wei Xian Tan, Leigh Madden, Lin Jin, Ji Yong Kenan Long, Fazila Aloweni, Yi Jia Angela Liew, Mandy Li Ling Tan, Shin Yuh Ang, Sivagame D O Maniya, Ibrahim Abdelwahab, Kian Ping Loh, Chia‐Hung Chen, David L. Becker, David I. Leavesley, John S. Ho, Chwee Teck Lim
Abstract
), and physicochemical parameters (temperature and pH) with a microfluidic wound exudate collector and flexible electronics for wireless, smartphone-based data readout. We demonstrate in situ multiplexed monitoring in a mouse wound model and also profile wound exudates from patients with venous leg ulcers. This technology may facilitate more timely and personalized wound management to improve chronic wound healing outcomes.
Topics & Concepts
In situPoint of careMicrofluidicsProfiling (computer programming)Biomedical engineeringNanotechnologyMultiplexingPoint-of-care testingComputer scienceMaterials scienceMedicineChemistryPathologyTelecommunicationsOperating systemOrganic chemistryWound Healing and TreatmentsAdvanced Sensor and Energy Harvesting Materials3D Printing in Biomedical Research