Diastereoselective trifunctionalization of pyridinium salts to access structurally crowded azaheteropolycycles
Zhaohui Cui, Kuan Zhang, Lijie Gu, Zhanwei Bu, Junwei Zhao, Qilin Wang
Abstract
-hydroxyl aromatic azomethine ylides has been established, which not only provided a convenient and rapid method to assemble challenging and architecturally crowded chroman-pyrrolidine-hydrogenated pyridine fused pentacycles, but also represented a rare successful example of the higher-order multifunctionalization of pyridiniums.
Topics & Concepts
PyridiniumChemistryCombinatorial chemistrySalt (chemistry)Medicinal chemistryOrganic chemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsAsymmetric Synthesis and Catalysis