Therapeutic efficacy of the novel SHP2 degrader SHP2-D26, alone or in combination, against lung cancer is associated with modulation of p70S6K/S6, Bim and Mcl-1
Yunfu Deng, Guangzhi Ma, Karin A. Vallega, Dongsheng Wang, Mingliang Wang, Changwei Wang, Shaomeng Wang, Suresh S. Ramalingam, Shi‐Yong Sun
Topics & Concepts
Cancer researchOsimertinibLung cancerOncologyCell growthCancerMedicinePharmacologyInternal medicineBiologyErlotinibEpidermal growth factor receptorBiochemistryProtein Tyrosine PhosphatasesGalectins and Cancer BiologyPI3K/AKT/mTOR signaling in cancer