Molecular Mechanisms Associated with Aging Kidneys and Future Perspectives
Min-Jee Jo, Joo-Kyung Lee, Ji Eun Kim, Gang-Jee Ko
Abstract
The rapid growth of the elderly population is making the need for extensive and advanced information about age-related organ dysfunction a crucial research area. The kidney is one of the organs most affected by aging. Aged kidneys undergo functional decline, characterized by a reduction in kidney size, decreased glomerular filtration rate, alterations in renal blood flow, and increased inflammation and fibrosis. This review offers a foundation for understanding the functional and molecular mechanisms of aging kidneys and for selecting identifying appropriate targets for future treatments of age-related kidney issues.
Topics & Concepts
KidneyRenal functionMedicineFibrosisInflammationRenal blood flowKidney diseasePhysiologyBioinformaticsPathologyInternal medicineIntensive care medicineBiologyDialysis and Renal Disease ManagementChronic Kidney Disease and DiabetesBirth, Development, and Health