<i>Lactobacillus acidophilus</i> LA85 ameliorates cyclophosphamide-induced immunosuppression by modulating Notch and TLR4/NF-κB signal pathways and remodeling the gut microbiota
Liangyu Xue, Zongqi Li, Jiabao Xue, Huiting Wang, Tao Wu, Rui Liu, Wenjie Sui, Min Zhang
Abstract
, and the intestinal Notch signaling pathway, and further discovered the potential mechanism of LA85 in intestinal mucosal repair. Based on the results of the study, we found that the effect of high doses of LA85 was more significant. Therefore, LA85 can be used as a dietary supplement to potentially enhance the immune capacity of patients.
Topics & Concepts
TLR4ImmunosuppressionLactobacillus acidophilusNotch signaling pathwaySignal transductionCyclophosphamideGut floraNF-κBSignal pathwayLactobacillusMicrobiologyBiologyChemistryCell biologyImmunologyBacteriaProbioticChemotherapyGeneticsGut microbiota and healthProbiotics and Fermented FoodsPediatric health and respiratory diseases