Diagnosis and management of tumor lysis syndrome.
Isha Puri, Deep Sharma, Krishna S. Gunturu, Andaleeb A. Ahmed
Abstract
Tumor lysis syndrome (TLS) is an oncological emergency characterized by a classic tetrad of hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia. Risk assessment and prophylactic therapy is critical in preventing this oncological emergency. Treatment of established TLS involves aggressive hydration, electrolyte management, and the use of hypouricemic agents.
Topics & Concepts
HyperphosphatemiaTumor lysis syndromeHyperuricemiaHyperkalemiaRasburicaseMedicineIntensive care medicineInternal medicineLysisImmunologyUric acidChemotherapyKidney diseaseMethemoglobinemia and Tumor Lysis SyndromeNeonatal Health and BiochemistryPorphyrin Metabolism and Disorders