Computer Simulation to Rationalize “Rational” Engineering of Glycoside Hydrolases and Glycosyltransferases
Joan Coines, Irene Cuxart, David Tezé, Carme Rovira
Abstract
-glycosidic bonds.
Topics & Concepts
GlycosyltransferaseGlycoside hydrolaseRational designGlycosidic bondProtein engineeringMechanism (biology)Directed evolutionChemistryGlycosylationBiochemistryGlycosideEnzymeSubstrate specificityComputational biologyComputer scienceCombinatorial chemistryStereochemistryBiologyGeneticsMutantPhilosophyGeneEpistemologyCarbohydrate Chemistry and SynthesisGlycosylation and Glycoproteins ResearchEnzyme Production and Characterization