Dimethyl fumarate ameliorates parkinsonian pathology by modulating autophagy and apoptosis via Nrf2-TIGAR-LAMP2/Cathepsin D axis
Mayuri Khot, Anika Sood, Kamatham Pushpa Tryphena, Poojitha Pinjala, Saurabh Srivastava, Shashi Bala Singh, Dharmendra Kumar Khatri
Topics & Concepts
AutophagyNeuroprotectionCell biologyCathepsin DNeurodegenerationApoptosisRotenoneOxidative stressChemistryDownregulation and upregulationDimethyl fumarateCathepsin BProgrammed cell deathCathepsinPhagosomeIntracellularBiologyMitochondrionBiochemistryPharmacologyImmunologyMedicineInternal medicineEnzymeMultiple sclerosisDiseaseGeneAutophagy in Disease and TherapyParkinson's Disease Mechanisms and TreatmentsCalcium signaling and nucleotide metabolism