UBXN2A suppresses the Rictor-mTORC2 signaling pathway, an established tumorigenic pathway in human colorectal cancer
Sanam Sane, Rekha Srinivasan, Rashaun Potts, Morgan Eikanger, Diana Zagirova, Jessica Freeling, Casey Reihe, Ryan Antony, Brij K. Gupta, Douglas Lynch, Jonathan Bleeker, Hassan Turaihi, Angela Pillatzki, Wei Zhou, Xu Luo, Michael Linnebacher, Diing D.M. Agany, Etienne Z. Gnimpiéba, Lisa E. Humphrey, Adrian R. Black, Khosrow Rezvani
Topics & Concepts
mTORC2mTORC1BiologyCancer researchProtein kinase BCarcinogenesisPI3K/AKT/mTOR pathwaySignal transductionCancerCell growthCell biologyGeneticsPI3K/AKT/mTOR signaling in cancerUbiquitin and proteasome pathwaysRenal cell carcinoma treatment