MicroRNA-146a switches microglial phenotypes to resist the pathological processes and cognitive degradation of Alzheimer's disease
Chunmei Liang, Ting Zou, Miaoping Zhang, Weihao Fan, Tianzhen Zhang, Yuling Jiang, Yujie Cai, Feng Chen, Xiongjin Chen, Yuanhong Sun, Bin Zhao, Yan Wang, Lili Cui
Abstract
. Moreover, transcriptional analysis confirmed that miR-146a opposed the pathological process of AD mainly through neuroinflammation-related pathways. In summary, our results provide sufficient evidence for the mechanism by which miR-146a opposes AD and strengthen the conclusion that miR-146a is a promising target for AD and other microglia-related diseases.
Topics & Concepts
PhenotypeMicrogliaPathologicalmicroRNADiseaseAlzheimer's diseaseResistDegradation (telecommunications)NeurosciencePathologyMedicineBiologyImmunologyInflammationGeneticsNanotechnologyMaterials scienceComputer scienceGeneLayer (electronics)TelecommunicationsNeuroinflammation and Neurodegeneration MechanismsMicroRNA in disease regulationAlzheimer's disease research and treatments