From Phenylhydrazone to 1<i>H</i>‐1,2,4‐Triazoles via Nitrification, Reduction and Cyclization
Liqiang Hao, Guodong Wang, Jian Sun, Jun Xu, Hongshuang Li, Guiyun Duan, Chengcai Xia, Pengfei Zhang
Abstract
Abstract Herein we report an annulation of phenylhydrazone via a tandem nitrification, reduction, cyclization protocol employing cobalt nitrate and 1,2‐dichloroethane to produce substituted 1 H ‐1,2,4‐triazoles. Notably, 1,2‐dichloroethane serves both the solvent and a hydrogen source for transfer hydrogenation. This methodology works under mild conditions, providing a direct approach for the synthesis of 1 H ‐1,2,4‐triazoles. magnified image
Topics & Concepts
ChemistryAnnulationTandemSolventCombinatorial chemistryReduction (mathematics)NitrificationDichloroethaneMedicinal chemistryOrganic chemistryCatalysisNitrogenGeometryMathematicsComposite materialMaterials scienceCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and Catalysis