CHOP and c-JUN up-regulate the mutant Z α1-antitrypsin, exacerbating its aggregation and liver proteotoxicity
Sergio Attanasio, Rosa Ferriero, Gwladys Gernoux, Rossella De Cegli, Annamaria Carissimo, Edoardo Nusco, Severo Campione, Jeffrey Teckman, Christian Mueller, Pasquale Piccolo, Nicola Brunetti‐Pierri
Abstract
transcription and play an important role in hepatic disease by increasing the burden of proteotoxic ATZ, particularly in the pediatric population.
Topics & Concepts
ProteotoxicityMutantCell biologyProtein aggregationChemistryBiologyGeneticsGeneEndoplasmic Reticulum Stress and DiseaseCalpain Protease Function and RegulationViral Infectious Diseases and Gene Expression in Insects