Dynamic functional connectivity patterns associated with dementia risk
Sophie Dautricourt, Julie Gonneaud, Brigitte Landeau, Vince D. Calhoun, Robin de Florès, Géraldine Poisnel, Salma Bougacha, Valentin Ourry, Edelweiss Touron, Elizabeth Kuhn, Harriet Demintz-King, Natalie L. Marchant, Denis Vivien, Vincent de La Sayette, Antoine Lutz, Gaël Chételat, Eider M. Arenaza‐Urquijo, Florence Allais, Claire André, Julien Asselineau, Alexandre Bejanin, Pierre Champetier, Gaël Chételat, Anne Chocat, Sophie Dautricourt, Robin de Florès, Marion Delarue, Stéphanie Egret, Francesca Felisatti, Eglantine Ferrand Devouge, Éric Frison, Julie Gonneaud, Marc Heidmann, Thien Huong Tran, Elizabeth Kuhn, Gwendoline Le Du, Brigitte Landeau, Valérie Lefranc, Antoine Lutz, Florence Mézenge, Inès Moulinet, Valentin Ourry, Cassandre Palix, Léo Paly, Géraldine Poisnel, Anne Quillard, Géraldine Rauchs, Stéphane Rehel, Florence Requier, Edelweiss Touron, Denis Vivien, Caitlin Ware, Sebastian Baez Lugo, Olga Klimecki, Patrik Vuilleumier, Thorsten Barnhofer, Fabienne Collette, Éric Salmon, Vincent de La Sayette, Pascal Delamillieure, Martine Batchelor, Axel Beaugonin, Francis Gheysen, Harriet Demnitz‐King, Natalie L. Marchant, Tim Whitfield, Corinne Schimmer, Miranka Wirth
Abstract
BACKGROUND: This study assesses the relationships between dynamic functional network connectivity (DFNC) and dementia risk. METHODS: DFNC of the default mode (DMN), salience (SN), and executive control networks was assessed in 127 cognitively unimpaired older adults. Stepwise regressions were performed with dementia risk and protective factors and biomarkers as predictors of DFNC. RESULTS: Associations were found between times spent in (i) a "weakly connected" state and lower self-reported engagement in early- and mid-life cognitive activity and higher LDL cholesterol; (ii) a "SN-negatively connected" state and higher blood pressure, higher depression score, and lower body mass index (BMI); (iii) a "strongly connected" state and higher self-reported engagement in early-life cognitive activity, Preclinical Alzheimer's cognitive composite-5 score, and BMI; and (iv) a "DMN-negatively connected" state and higher self-reported engagement in early- and mid-life stimulating activities and lower LDL cholesterol and blood pressure. The lower number of state transitions was associated with lower brain perfusion. CONCLUSION: DFNC states are differentially associated with dementia risk and could underlie reserve.