Reviving the role of MET in liver cancer therapy and vaccination: an autophagic perspective
Xing Huang, Gang Zhang, Xueli Bai, Tingbo Liang
Abstract
Past failures in clinical trials have dampened the enthusiasm for studying the HGF receptor MET and postponed the development of MET-targeted drugs for cancer therapy. However, new evidence suggests that, at least in liver cancer, MET is still a promising therapeutic target, and may also be a potential target for cancer vaccines. This paper briefly highlights novel research advances in this rapidly-evolving field in the perspective of autophagy, and discusses future directions for further investigation of MET-based cancer therapy and vaccination.
Topics & Concepts
MedicineCancerClinical trialPerspective (graphical)AutophagyCancer therapyLiver cancerVaccinationTargeted therapyIntensive care medicineImmunologyInternal medicineBiologyBiochemistryComputer scienceArtificial intelligenceApoptosisAutophagy in Disease and TherapyLiver physiology and pathologyPhagocytosis and Immune Regulation