Role of the DNA Binding Activity of Herpes Simplex Virus 1 VP22 in Evading AIM2-Dependent Inflammasome Activation Induced by the Virus
Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi
Abstract
VP22, a major component of the HSV-1 virion tegument, is conserved in alphaherpesviruses and has structural similarity to ORF52, a component of the virion tegument that is well conserved in gammaherpesviruses. Although the potential DNA binding activity of VP22 was discovered decades ago, its significance in the HSV-1 life cycle is poorly understood.
Topics & Concepts
BiologyAIM2InflammasomeHerpes simplex virusVirologyVirusDNADNA virusGeneticsGeneGenomeReceptorHerpesvirus Infections and TreatmentsInflammasome and immune disordersinterferon and immune responses