Enantioseparation of <i>P</i>-Stereogenic Secondary Phosphine Oxides and Their Stereospecific Transformation to Various Tertiary Phosphine Oxides and a Thiophosphinate
Bence Varga, Péter Szemesi, Petra Nagy, Réka Herbay, Tamás Holczbauer, Elemér Fogassy, György Keglevich, Péter Bagi
Abstract
-stereogenic tertiary phosphine oxides and a thiophosphinate in stereospecific Michaelis-Becker, Hirao, or Pudovik reactions.
Topics & Concepts
StereocenterPhosphineChemistryStereospecificityEnantiopure drugEnantiomerAlkylEnantiomeric excessOrganic chemistryMedicinal chemistryStereochemistryEnantioselective synthesisCatalysisAsymmetric Hydrogenation and CatalysisOrganophosphorus compounds synthesisPhosphorus compounds and reactions