Expanding the reaction toolbox for nanoscale direct-to-biology PROTAC synthesis and biological evaluation
Rebecca Stevens, Harry J. Shrives, Jenni Cryan, Diana Klimaszewska, Peter Stacey, Glenn A. Burley, John D. Harling, David Battersby, Afjal H. Miah
Abstract
Ar, palladium-mediated cross-coupling and alkylation, in D2B format. Second, the utility of these alternative reactions is demonstrated by rapidly identifying developable PROTACs for a range of protein targets.
Topics & Concepts
NanotechnologyToolboxNanoscopic scaleSynthetic biologyThroughputComputational biologyChemistryComputer scienceBiochemical engineeringMaterials scienceBiologyEngineeringTelecommunicationsWirelessProgramming languageProtein Degradation and InhibitorsCAR-T cell therapy researchMonoclonal and Polyclonal Antibodies Research