Uptake of Upconverting Nanoparticles by Breast Cancer Cells: Surface Coating versus the Protein Corona
Evelina Voronovič, Artiom Skripka, Greta Jarockytė, Marija Ger, Dalius Kučiauskas, Algirdas Kaupinis, Mindaugas Valius, Ričardas Rotomskis, Fiorenzo Vetrone, Vitalijus Karabanovas
Abstract
-coated RENPs is larger and highly dynamic. Moreover, biocompatibility, accumulation, and cytotoxicity of various RENPs in cancer cells have been evaluated. On the basis of the cellular imaging, supported by the inhibition studies, it was revealed that RENPs are internalized by endocytosis and that specific endocytic routes are PC composition dependent. Overall, these results are essential to fill the gaps in the fundamental understanding of the nano-biointeractions of RENPs, pertinent for their envisioned application in biomedicine.
Topics & Concepts
EndocytosisBiocompatibilityMaterials scienceNanoparticleNanotechnologyDrug deliveryBiophysicsNanomedicineCancer cellSurface modificationProtein adsorptionEndocytic cyclePhospholipidCellCancerChemistryBiochemistryBiologyPolymerPhysical chemistryMembraneGeneticsComposite materialMetallurgyNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsCharacterization and Applications of Magnetic Nanoparticles