Defining lung cancer stem cells exosomal payload of miRNAs in clinical perspective
Beatrice Aramini, Valentina Masciale, Khawaja Husnain Haider
Abstract
"exosomes" (small membrane vesicles (30-100 nm), the derivation of which lies in the luminal membranes of multi-vesicular bodies) released by fusion with the cell membrane is gaining popularity. Whether exosomes play a significant role in maintaining a dynamic equilibrium state between CSCs and non-CSCs and their mechanism of activity is as yet unknown. Future studies on CSC-related exosomes will provide new perspectives for precision-targeted treatment strategies.
Topics & Concepts
MicrovesiclesCancer stem cellmicroRNAParacrine signallingCancer researchStem cellLung cancerCancerMechanism (biology)Cancer cellExosomeMedicineBiologyBioinformaticsComputational biologyCell biologyOncologyInternal medicineGeneGeneticsPhilosophyEpistemologyReceptorExtracellular vesicles in diseaseMicroRNA in disease regulationCancer-related molecular mechanisms research