Topologically switchable and gated transcription machinery
Pu Zhang, Amit Fischer, Yu Ouyang, Yang Sung Sohn, Rachel Nechushtai, Junji Zhang, He Tian, Chunhai Fan, Itamar Willner
Abstract
-ion/KP topologically triggered DNA tetrahedra promoter-transcription scaffold, for the replication of the MG RNA aptamer, and T7 RNA polymerase are integrated into DNA-based carboxymethyl cellulose hydrogel microcapsules acting as cell-like assemblies. The switchable, reversible transcription of the MG RNA aptamer in a cell-like containment is introduced.
Topics & Concepts
Transcription (linguistics)Computational biologyBiologyComputer sciencePhilosophyLinguisticsAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid ChemistryGenomics and Chromatin Dynamics