Flow Electrosynthesis of Sulfoxides, Sulfones, and Sulfoximines without Supporting Electrolytes
Nasser Amri, Thomas Wirth
Abstract
An efficient electrochemical flow process for the selective oxidation of sulfides to sulfoxides and sulfones and of sulfoxides to N-cyanosulfoximines has been developed. In total, 69 examples of sulfoxides, sulfones, and N-cyanosulfoximines have been synthesized in good to excellent yields and with high current efficiencies. The synthesis was assisted and facilitated through a supporting electrolyte-free, fully automated electrochemical protocol that highlights the advantages of flow electrolysis.
Topics & Concepts
ElectrosynthesisElectrolysisElectrochemistryElectrolyteSupporting electrolyteContinuous flowChemistryElectrodeBiochemical engineeringEngineeringPhysical chemistrySulfur-Based Synthesis TechniquesSynthesis and Catalytic ReactionsRadical Photochemical Reactions