Dual-Targeting Polymer Nanoparticles Efficiently Deliver DNA Vaccine and Induce Robust Prophylactic Immunity against Spring Viremia of Carp Virus Infection
Chen Zhang, Peng‐Qi Zhang, Sheng Guo, Zhao Zhao, Gao‐Xue Wang, Bin Zhu
Abstract
Spring viremia of carp virus (SVCV) affects global cyprinid fish farming industry, with no available commercial vaccine. Herein, we developed a dual-targeting polymer nanovaccine (MCS-PCHG) by using mannose and common carp IgM heavy chain C H 3 region (CH3) as antigen presenting cell (APCs) recognition moiety, attaining the effective delivery of antigen. This dual-targeting polymer vaccine can efficiently activate the APCs, and further induce robust and durable adaptive immune response with good protection against SVCV infection.
Topics & Concepts
ViremiaCarpVirologyVirusImmune systemMannose receptorDNA vaccinationAntigenAcquired immune systemBiologyImmunityImmunologyImmunizationFish <Actinopterygii>GeneticsFisheryIn vitroMacrophageRNA Interference and Gene DeliveryAquaculture disease management and microbiotaAnimal Virus Infections Studies