Gut Microbiota Modulate CD8 T Cell Responses to Influence Colitis-Associated Tumorigenesis
Amy I. Yu, Lili Zhao, Kathryn A. Eaton, Sharon L. Ho, Jiachen Chen, Sara Poe, James T. Becker, Allison Gonzalez, Delaney McKinstry, Muneer Hasso, Jonny Mendoza‐Castrejon, Joel Whitfield, Charles C. Koumpouras, Patrick D. Schloss, Eric C. Martens, Grace Chen
Abstract
T cells in tumors and adjacent tissues compared with mice that develop fewer tumors. Notably, intratumoral T cells in mice that develop more tumors exhibit increased exhaustion. Thus, these studies suggest that microbial dysbiosis can contribute to colon tumor susceptibility by hyperstimulating CD8 T cells to promote chronic inflammation and early T cell exhaustion, which can reduce anti-tumor immunity.
Topics & Concepts
DysbiosisCarcinogenesisBiologyCD8Immune systemMicrobiomeInflammationImmunologyColorectal cancerGut floraColitisCytotoxic T cellCancer researchT cellImmunityCancerBioinformaticsGeneticsIn vitroGut microbiota and healthImmune Cell Function and InteractionCancer Immunotherapy and Biomarkers