Direct sulfonamidation of (hetero)aromatic C–H bonds with sulfonyl azides: a novel and efficient route to<i>N</i>-(hetero)aryl sulfonamides
Zhi Liu, Abdol Ghaffar Ebadi, Mohsen Toughani, Nihat Mert, Esmail Vessally
Abstract
-(hetero)aryl sulfonamides where non-toxic nitrogen gas forms as the sole by-product. This review highlights recent advances and developments (2012-2020) in this fast growing research area with emphasis on the mechanistic features of the reactions.
Topics & Concepts
SulfonylArylChemistrySulfonamideAromaticityMedicinal chemistryOrganic chemistryCombinatorial chemistryMoleculeAlkylSulfur-Based Synthesis TechniquesSynthesis and Catalytic ReactionsCatalytic C–H Functionalization Methods