Natural or Synthetic RNA Delivery: A Stoichiometric Comparison of Extracellular Vesicles and Synthetic Nanoparticles
Daniel E. Murphy, Olivier G. de Jong, Martijn J.W. Evers, Maratussholikhah Nurazizah, Raymond M. Schiffelers, Pieter Vader
Abstract
transfection reagents. We found that EVs delivered RNA several orders of magnitude more efficiently than these synthetic systems. This finding supports the continued research into EVs as potential RNA delivery vehicles.
Topics & Concepts
RNANanotechnologySynthetic biologyChemistryExtracellular vesiclesComputational biologyCell biologyBiologyBiochemistryMaterials scienceGeneExtracellular vesicles in diseaseRNA Interference and Gene DeliveryMicroRNA in disease regulation