Isothiourea and Brønsted Acid Cooperative Catalysis: Enantioselective Construction of Dihydropyridinones
Yu‐Chen Zhang, Rui‐Long Geng, Jin Song, Liu‐Zhu Gong
Abstract
Asymmetric annulation of bench-stable α,β-unsaturated aryl esters with enamines was realized via cooperative catalysis of chiral isothiourea and Brønsted acid. This reaction proceeds via a chiral α,β-unsaturated acyl ammonium intermediate and offers a rapid access to functionalized 3,4-dihydropyridin-2-ones in high yields and excellent enantioselectivities.
Topics & Concepts
ChemistryEnantioselective synthesisBrønsted–Lowry acid–base theoryCatalysisAnnulationAmmoniumArylCombinatorial chemistryOrganic chemistryOrganocatalysisReaction conditionsAlkylAsymmetric Synthesis and CatalysisSynthesis and Catalytic ReactionsSynthetic Organic Chemistry Methods