Intussusception and COVID-19 in Infants: Evidence for an Etiopathologic Correlation
Federico Scottoni, Giovanni Giuseppe Giobbe, Elisa Zambaiti, S Khalaf, Neil J. Sebire, Joe Curry, Paolo De Coppi, Fabrizio Gennari
Abstract
Nonrespiratory conditions related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have been largely described. Ileocolic intussusception has been reported in association with SARS-CoV-2 infection in 10 children, raising the possibility of an etiopathologic role for the virus, but none of these cases documented tissue pathology that would have supported SARS-CoV-2 intestinal inflammation. We report 2 cases of intussusception in patients with SARS-CoV-2 infection who were treated at different pediatric tertiary centers in Europe and provide evidence of the presence of the virus in mesenteric and intestinal tissues of the patients.