Urolithin A protects dopaminergic neurons in experimental models of Parkinson's disease by promoting mitochondrial biogenesis through the SIRT1/PGC-1α signaling pathway
Jia Liu, Jingjing Jiang, Jingru Qiu, Liyan Wang, Jing Zhuo, Baozhu Wang, Deqing Sun, Shuyan Yu, Haiyan Lou
Abstract
SIRT1-PGC-1α signaling pathway. Taken together, these data provide new insights into the novel role of UA in regulating mitochondrial dysfunction and suggest that UA may have potential therapeutic applications for PD.
Topics & Concepts
NeurotoxicityNeuroprotectionMitochondrial biogenesisDopaminergicParkinson's diseasePharmacologyMPTPMitochondrionPINK1Programmed cell deathChemistryApoptosisDopamineBiologyMedicineNeuroscienceCell biologyDiseaseBiochemistryInternal medicineParkinToxicityPomegranate: compositions and health benefitsAntioxidant Activity and Oxidative StressBioactive Compounds in Plants