Litcius/Paper detail

Identification of a new small molecule that initiates ferroptosis in cancer cells by inhibiting the system Xc− to deplete GSH

Xianling Ning, Hailong Qi, Yuyao Yuan, Ridong Li, Yuanyuan Wang, Zhiqiang Lin, Yuxin Yin

2022European Journal of Pharmacology11 citationsDOI

Topics & Concepts

GPX4NecroptosisProgrammed cell deathLipid peroxidationCancer cellApoptosisIn vivoCell biologyCancer researchInducerChemistryGlutathioneCancerBiochemistryBiologyPharmacologyOxidative stressGeneGeneticsGlutathione peroxidaseEnzymeFerroptosis and cancer prognosisCancer, Lipids, and MetabolismRNA modifications and cancer