Identification of a new small molecule that initiates ferroptosis in cancer cells by inhibiting the system Xc− to deplete GSH
Xianling Ning, Hailong Qi, Yuyao Yuan, Ridong Li, Yuanyuan Wang, Zhiqiang Lin, Yuxin Yin
Topics & Concepts
GPX4NecroptosisProgrammed cell deathLipid peroxidationCancer cellApoptosisIn vivoCell biologyCancer researchInducerChemistryGlutathioneCancerBiochemistryBiologyPharmacologyOxidative stressGeneGeneticsGlutathione peroxidaseEnzymeFerroptosis and cancer prognosisCancer, Lipids, and MetabolismRNA modifications and cancer