Efficient antitumor effects of a novel oncolytic adenovirus fully composed of species B adenovirus serotype 35
Ryosuke Ono, Kosuke Takayama, Fuminori Sakurai, Hiroyuki Mizuguchi
Abstract
tumor cell lysis activities in the presence of anti-Ad5 and naive serum. OAd35 significantly suppressed growth of the subcutaneous CAR-positive and CAR-negative tumors following intratumoral administration. These results indicated that OAd35 is a promising alternative oncolytic virus for OAd5.
Topics & Concepts
Oncolytic virusOncolytic adenovirusCoxsackievirusVirologyBiologySerotypeAntibodyVirusCell cultureAdenoviridaeCancer researchImmunologyGenetic enhancementGeneEnterovirusBiochemistryGeneticsVirus-based gene therapy researchCAR-T cell therapy researchViral Infectious Diseases and Gene Expression in Insects