Involvement of the Expression of G Protein-Coupled Receptors in Schizophrenia
Raluka Kalinovic, Andrei Pascariu, Gabriela Vlad, Diana Nițușcă, Andreea Sălcudean, Ioan Ovidiu Sîrbu, Cătălin Marian, V.R. Enatescu
Abstract
The expression of GPCRs has been associated with schizophrenia, and their expression may induce morphological changes in brain regions responsible for schizophrenia and disease-specific behavioral changes. The articles included in this review were selected using keywords and databases of scientific research websites. The expressions of GPRs have different involvements in schizophrenia, some increase the risk while others provide protection, and they may also be potential targets for new treatments. Proper evaluation of these factors is essential to have a better therapeutic response with a lower rate of chronicity and thus improve the long-term prognosis.