Chemical approaches for the enhancement of porphyrin skeleton-based photodynamic therapy
Yuyan Lin, Tao Zhou, Renren Bai, Yuanyuan Xie
Abstract
With the development of photodynamic therapy (PDT), remarkable studies have been conducted to generate photosensitisers (PSs), especially porphyrin PSs. A variety of chemical modifications of the porphyrin skeleton have been introduced to improve cellular delivery, stability, and selectivity for cancerous tissues. This review aims to highlight the developments in porphyrin-based structural modifications, with a specific emphasis on the role of PDT in anticancer treatment and the design of PSs to achieve a synergistic effect on multiple targets.
Topics & Concepts
Photodynamic therapyPorphyrinChemistryCombinatorial chemistryNanotechnologyMaterials sciencePhotochemistryOrganic chemistryPhotodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsPorphyrin and Phthalocyanine Chemistry